---------------------PK NEWS---------------------------------------------- PK is an R package for inference for PK parameters in complete and incomplete data designs based on non-compartmental methods. If you are using the package, please cite it as Jaki T and Wolfsegger MJ (2011) Estimation of pharmacokinetic parameters with the R package PK. Pharmaceutical Statistics. Vol 10(No 3), 294-288. DOI: 10.1002/pst.449" Question or suggestions about the package can be send to jaki.thomas@gmail.com or martin.wolfsegger@takeda.com --------------------CHANGE LOG-------------------------------------------- Version 1.3-6 o Internal changes to comply with CRAN rules -------------------------------------------------------------------------- Version 1.3-5 o Internal changes to ensure compatability with newer versions of R -------------------------------------------------------------------------- Version 1.3-4 o Fixed a bug in auc.ssd, auc.batch, eqv.batch -------------------------------------------------------------------------- Version 1.3-3 o Removal of depreciated function call -------------------------------------------------------------------------- Version 1.3-2 o A bug during start-up is corrected -------------------------------------------------------------------------- Version 1.3-1 o depreciated functions as.real replaced by as.double -------------------------------------------------------------------------- Version 1.3-0 o Flexible batch designs (Jaki & Wolfsegger, Statistics in Medicine 2012) implemented. These designs allow the same timepoints to be used in different batches. Functions updated: auc.batch Help files updated: auc.batch, eqv.batch o Methods to compute PK parameters such as Clearance in flexible batch designs have been added in functions nca and nca.batch o Help for nca updated o Help for eqv.ssd, eqv.batch and eqv.complete has been merged with eqv -------------------------------------------------------------------------- Version 1.2-5 o Code in biexp and lee updated o Several examples in help files biexp and lee added -------------------------------------------------------------------------- Version 1.2-4 o The help file for the function nca has been corrected o Citation information updated -------------------------------------------------------------------------- Version 1.2-3 o A bug in an internal function to handle the data argument in batch designs fixed o Citation information updated o A bug in the nca.complete function fixed o A bug in the summary function fixed -------------------------------------------------------------------------- Version 1.2-2 o A repeated dose toxicity dataset included o Help on nca function expanded o A bug in the print function fixed o auc.complete updated to handle individual AUCs o Additional example in help for auc.complete included o Function nca.complete included -------------------------------------------------------------------------- Version 1.2-1 o Default option for method lee changed to ols o Functionality to create plots by group included o Some formating changes in the print/summary functions o Bug in print.PKtest fixed o Bug in test fixed -------------------------------------------------------------------------- Version 1.2-0 o Multiple datasets included o Bug in auc.batch fixed o Functions can now be called using data in FDA SEND format - http://www.cdisc.org/send o Functions est, ci and test have been included to obtain point estimates, confidence intervals and hypothesis tests o Functions auc, eqv, nca have been aligned o Methods to test for bioequivalence in batch designs for independent and dependent aucs have been added in functions eqv and eqv.batch o Methods to compute PK parameters such as MRT and Clearance in serial sampling designs have been added in functions nca and nca.ssd o Multiple references added and updated