MVPapp: Interactive Platform for Pharmacometrics Model Visualization and Simulation

An interactive 'shiny' application for exploring pharmacometrics models with minimal setup. Users can explore model structures, parameters and dosing regimens with 'mrgsolve', and compare simulations with observed data. Additional features include parameter sensitivity analysis, non-compartmental analysis (NCA), data exploration, variability assessment with virtual populations, and optional AI-assisted model translation. For design considerations of the app, see Choy et al. (2025) <doi:10.1002/psp4.70023>.

Version: 1.0.0
Depends: R (≥ 4.1)
Imports: bslib (≥ 0.5.1), cowplot, data.table (≥ 1.14.2), dplyr (≥ 1.1.0), DT, flextable (≥ 0.6.10), ggplot2 (≥ 3.4.4), grid, graphics, grDevices, htmltools (≥ 0.5.5), magrittr, mrgsolve (≥ 1.5.0), plotly (≥ 4.10.1), rhandsontable (≥ 0.3.8), rlang (≥ 1.0.0), scales, shiny (≥ 1.7.4.1), shinyAce, shinyBS (≥ 0.61.1), shinycssloaders, shinydashboard (≥ 0.7.2), shinyFiles, shinyjs (≥ 1.0), shinythemes, shinyWidgets (≥ 0.8.0), stats, stringr, tidyr, tools, utils, zip
Suggests: curl, ellmer (≥ 0.4.0), GGally, httr2, knitr, mime, ncar, NonCompart, nonmem2mrgsolve, nonmem2rx, pdftools, rmarkdown, shinyalert, spelling, testthat (≥ 3.0.0)
Published: 2026-11-13
DOI: 10.32614/CRAN.package.MVPapp (may not be active yet)
Author: Steve Choy [aut, cre, cph], Jin Gyu Kim [aut], Matthew Fidler [ctb], Jason Bryer [ctb, cph] (Author of the ShinyDemo package, from which run_mvp() is adapted)
Maintainer: Steve Choy <steve.choy at outlook.com>
License: GPL (≥ 3)
URL: https://github.com/stevechoy/MVPapp, https://stevechoy.github.io/MVPapp/
NeedsCompilation: no
Additional_repositories: https://stevechoy.r-universe.dev
Language: en-US
Citation: MVPapp citation info
Materials: README, NEWS
CRAN checks: MVPapp results

Documentation:

Reference manual: MVPapp.html , MVPapp.pdf
Vignettes: Automatic Model Translation (source, R code)
Effective Exploratory Data Analysis (source, R code)
Supplying Passworded Models (source, R code)

Downloads:

Package source: MVPapp_1.0.0.tar.gz
Windows binaries: r-devel: not available, r-release: MVPapp_1.0.0.zip, r-oldrel: MVPapp_1.0.0.zip
macOS binaries: r-release (arm64): MVPapp_1.0.0.tgz, r-oldrel (arm64): MVPapp_1.0.0.tgz, r-release (x86_64): MVPapp_1.0.0.tgz, r-oldrel (x86_64): not available

Linking:

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